Article
Dicer function is essential for lung epithelium morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006
Harris Kelley S, Zhang Zhen, McManus Michael T, Harfe Brian D, Sun Xin
Abstract excerpt
DICER is a key enzyme that processes microRNA and small interfering RNA precursors into their short mature forms, enabling them to regulate gene expression. Only a single Dicer gene exists in the mouse genome, and it is broadly expressed in developing tissues. Dicer-null mutants die before gastrulation. Therefore, to study Dicer function in the later event of lung formation, we inactivated it in the mouse lung...
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