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Article

Glycosphingolipids control the extracellular gradient of the Drosophila EGFR ligand Gurken.

Development (Cambridge, England) - 1 Feb 2009

Pizette Sandrine, Rabouille Catherine, Cohen Stephen M, Thérond Pascal

Abstract excerpt

Glycosphingolipids (GSLs) are present in all eukaryotic membranes and are implicated in neuropathologies and tumor progression in humans. Nevertheless, their in vivo functions remain poorly understood in vertebrates, partly owing to redundancy in the enzymes elongating their sugar chains. In Drosophila, a single GSL biosynthetic pathway is present that relies on the activity of the Egghead and Brainiac...

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Identifiers

PMID: 19144719
DOI: 10.1242/dev.031104

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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