An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg.

doi:10.1016/s0092-8674(00)81767-5

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Article

An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg.

Cell - 30 Oct 1998

Wasserman J D, Freeman M

Abstract excerpt

Intercellular signaling through the EGF receptor (EGFR) patterns the Drosophila egg. The TGF alpha-like ligand Gurken signals from the oocyte to the receptor in the overlying somatic follicle cells. We show that in the dorsal follicle cells this initial paracrine signaling event triggers an autoc...

Topics

Animals
Autocrine Communication
Body Patterning
Drosophila Proteins
Drosophila melanogaster
Egg Shell
Epidermal Growth Factor
ErbB Receptors
Eye Proteins
Female
Genes, Essential
Insect Proteins
Membrane Proteins
Models, Biological
Mutation
Nerve Tissue Proteins
Neuregulins
Oocytes

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