Article
Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 2012
Dahlgaard Katja, Jung Anita, Qvortrup Klaus, Clausen Henrik, Kjaerulff Ole, Wandall Hans H
Abstract excerpt
Glycosphingolipids (GSLs) are of fundamental importance in the nervous system. However, the molecular details associated with GSL function are largely unknown, in part because of the complexity of GSL biosynthesis in vertebrates. In Drosophila, only one major GSL biosynthetic pathway exists, controlled by the glycosyltransferase Egghead (Egh). Here we discovered that loss of Egh causes overgrowth of peripheral...
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