Article
Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complex.
Diabetes, obesity & metabolism - 1 Feb 2009
Morahan G, Mehta M, McKinnon E, James I
Abstract excerpt
AIM: Type 1 diabetes susceptibility is influenced by a number of genes, of which those with the strongest effects map to the human leucocyte antigen (HLA) complex. Evidence for linkage of non-HLA genes in several affected sib-pair analyses was increased if the HLA or gender status of the sibs was...
Topics
- Diabetes Mellitus, Type 1
- Female
- Genes, MHC Class I
- Genes, MHC Class II
- Genes, Recessive
- Genetic Heterogeneity
- Genetic Predisposition to Disease
- Genotype
- HLA Antigens
- Humans
- Linkage Disequilibrium
- Male
- Pedigree
- Polymorphism, Single Nucleotide