Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.

Diabetes - 1 Mar 2011

Morahan Grant, Mehta Munish, James Ian, Chen Wei-Min, Akolkar Beena, Erlich Henry A, Hilner Joan E, Julier Cécile, Nerup Jørn, Nierras Concepcion, Pociot Flemming, Todd John A, Rich Stephen S

Abstract excerpt

OBJECTIVE: Interactions between genetic and environmental factors lead to immune dysregulation causing type 1 diabetes and other autoimmune disorders. Recently, many common genetic variants have been associated with type 1 diabetes risk, but each has modest individual effects. Familial clustering of type 1 diabetes has not been explained fully and could arise from many factors, including undetected genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Genetic Linkage

Share to Genetic Loci

Share to Genetic Predisposition to Disease

Share to Risk Factors

Share to Siblings

Source

Open in PubMed Open full text

Identifiers

PMID: 21266329
DOI: 10.2337/db10-1195
PMCID: PMC3046821

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.PMID 21266329Read ↗

Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families.Semantic proximity Read ↗

Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.Semantic proximity Read ↗

Genetic susceptibility factors in type 1 diabetes: linkage, disequilibrium and functional analyses.Semantic proximity Read ↗

Genetics of type 1 diabetes.Semantic proximity Read ↗

Confirmation of novel type 1 diabetes risk loci in families.Semantic proximity Read ↗

Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complex.Semantic proximity Read ↗

A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.Semantic proximity Read ↗

Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.Semantic proximity Read ↗

Genetics of Type 1 Diabetes: What's Next?Semantic proximity Read ↗

Age and sex based genetic locus heterogeneity in type 1 diabetes.Semantic proximity Read ↗

A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions.Semantic proximity Read ↗

Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.