Article
Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21.
Human molecular genetics - 1 Jul 1997
Merriman T, Twells R, Merriman M, Eaves I, Cox R, Cucca F, McKinney P, Shield J, Baum D, Bosi E, Pozzilli P, Nisticò L, Buzzetti R, Joner G, Rønningen K S, Rønningen K, Thorsby E, Undlien D, Pociot F, Nerup J, Bain S, Barnett A, Todd J
Abstract excerpt
Type 1 diabetes is a common polygenic disease. Fine mapping of polygenes by affected sibpair linkage analysis is not practical and allelic association or linkage disequilibrium mapping will have to be employed to attempt to detect founder chromosomes. Given prior evidence of linkage of the Jk-D18...
Topics
- Adolescent
- Adult
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 18
- Diabetes Mellitus, Type 1
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Linkage Disequilibrium