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Article

The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene.

American journal of human genetics - 1 Mar 1999

Lie B A, Todd J A, Pociot F, Nerup J, Akselsen H E, Joner G, Dahl-Jørgensen K, Rønningen K S, Thorsby E, Undlien D E

Abstract excerpt

The human leukocyte antigen (HLA) complex, encompassing 3.5 Mb of DNA from the centromeric HLA-DPB2 locus to the telomeric HLA-F locus on chromosome 6p21, encodes a major part of the genetic predisposition to develop type 1 diabetes, designated "IDDM1." A primary role for allelic variation of the class II HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci has been established. However, studies of animals and humans have...

Topics

Alleles
Case-Control Studies
Chromosomes, Human, Pair 6
Diabetes Mellitus, Type 1
Exons
Genes, MHC Class II
Genetic Predisposition to Disease
HLA Antigens
Histocompatibility Testing
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Repeats

Models, Statistical

Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 10053014
DOI: 10.1086/302283
PMCID: PMC1377797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene.PMID 10053014Read ↗

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A second component of HLA-linked susceptibility to type 1 diabetes maps to class I region.Semantic proximity Read ↗

Deciphering the Genetic Landscape: Exploring the Relationship Between HLA-DQA1, HLA-DQB1, and HLA-DRB1 Genes in Diabetes MellitusSemantic proximity Read ↗

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Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.Semantic proximity Read ↗

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