Article
Conserved extended haplotypes discriminate HLA-DR3-homozygous Basque patients with type 1 diabetes mellitus and celiac disease.
Genes and immunity - 1 Oct 2006
Bilbao J R, Calvo B, Aransay A M, Martin-Pagola A, Perez de Nanclares G, Aly T A, Rica I, Vitoria J C, Gaztambide S, Noble J, Fain P R, Awdeh Z L, Alper C A, Castaño L
Abstract excerpt
The major susceptibility locus for type 1 diabetes mellitus (T1D) maps to the human lymphocyte antigen (HLA) class II region in the major histocompatibility complex on chromosome 6p21. In southern European populations, like the Basques, the greatest risk to T1D is associated with DR3 homo- and heterozygosity and is comparable to that of DR3/DR4, the highest risk genotype in northern European populations. Celiac...
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