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Article

Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children.

Diabetes - 1 Jul 2020

Zhao Lue Ping, Papadopoulos George K, Kwok William W, Moustakas Antonis K, Bondinas George P, Larsson Helena Elding, Ludvigsson Johnny, Marcus Claude, Samuelsson Ulf, Wang Ruihan, Pyo Chul-Woo, Nelson Wyatt C, Geraghty Daniel E, Lernmark Åke

Abstract excerpt

HLA-DQA1 and -DQB1 are strongly associated with type 1 diabetes (T1D), and DQ8.1 and DQ2.5 are major risk haplotypes. Next-generation targeted sequencing of HLA-DQA1 and -DQB1 in Swedish newly diagnosed 1- to 18 year-old patients (n = 962) and control subjects (n = 636) was used to construct abbreviated DQ haplotypes, converted into amino acid (AA) residues, and assessed for their associations with T1D. A...

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Identifiers

PMID: 32245799
DOI: 10.2337/db20-0075
PMCID: PMC7306123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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