Article
A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2004
Takano Atsuko, Uchiyama Makoto, Kajimura Naofumi, Mishima Kazuo, Inoue Yuichi, Kamei Yuichi, Kitajima Tsuyoshi, Shibui Kayo, Katoh Masaaki, Watanabe Tsuyoshi, Hashimotodani Yuki, Nakajima Toru, Ozeki Yuji, Hori Toru, Yamada Naoto, Toyoshima Ryoichi, Ozaki Norio, Okawa Masako, Nagai Katsuya, Takahashi Kiyohisa, Isojima Yasushi, Yamauchi Toshio, Ebisawa Takashi
Abstract excerpt
Recent studies have shown that functional variations in clock genes, which generate circadian rhythms through interactive positive/negative feedback loops, contribute to the development of circadian rhythm sleep disorders in humans. Another potential candidate for rhythm disorder susceptibility is casein kinase I epsilon (CKIepsilon), which phosphorylates clock proteins and plays a pivotal role in the circadian...
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