Article
Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells.
The Journal of biological chemistry - 20 Mar 2009
Maron Bradley A, Zhang Ying-Yi, Handy Diane E, Beuve Annie, Tang Shiow-Shih, Loscalzo Joseph, Leopold Jane A
Abstract excerpt
Hyperaldosteronism is associated with impaired endothelium-dependent vascular reactivity owing to increased reactive oxygen species and decreased bioavailable nitric oxide (NO(.)); however, the effects of aldosterone on vasodilatory signaling pathways in vascular smooth muscle cells (VSMC) remain unknown. Soluble guanylyl cyclase (GC) is a heterodimer that is activated by NO(.) to convert cytosolic GTP to cGMP, a...
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