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Article

Guanylyl cyclase sensitivity to nitric oxide is protected by a thiol oxidation-driven interaction with thioredoxin-1.

The Journal of biological chemistry - 1 Sept 2017

Huang Can, Alapa Maryam, Shu Ping, Nagarajan Narayani, Wu Changgong, Sadoshima Junichi, Kholodovych Vladyslav, Li Hong, Beuve Annie

Abstract excerpt

Nitric oxide (NO) modulates many physiological events through production of cGMP from its receptor, the NO-sensitive guanylyl cyclase (GC1). NO also appears to function in a cGMP-independent manner, via S-nitrosation (SNO), a redox-based modification of cysteine thiols. Previously, we have shown that S-nitrosated GC1 (SNO-GC1) is desensitized to NO stimulation following prolonged NO exposure or under...

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Identifiers

PMID: 28659344
DOI: 10.1074/jbc.M117.787390
PMCID: PMC5582831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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