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Article

Identification of a redox-sensitive switch within the JAK2 catalytic domain.

Free radical biology & medicine - 15 Mar 2012

Smith John K, Patil Chetan N, Patlolla Srikant, Gunter Barak W, Booz George W, Duhé Roy J

Abstract excerpt

Four cysteine residues (Cys866, Cys917, Cys1094, and Cys1105) have direct roles in cooperatively regulating Janus kinase 2 (JAK2) catalytic activity. Additional site-directed mutagenesis experiments now provide evidence that two of these residues (Cys866 and Cys917) act together as a redox-sensitive switch, allowing JAK2's catalytic activity to be directly regulated by the redox state of the cell. We created...

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Source

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Identifiers

PMID: 22281400
DOI: 10.1016/j.freeradbiomed.2011.12.025
PMCID: PMC3319112

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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