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Article

Nitric oxide synthase (NOS2) mutation in Dahl/Rapp rats decreases enzyme stability.

Circulation research - 17 Aug 2001

Ying W Z, Xia H, Sanders P W

Abstract excerpt

The pathogenesis of salt-sensitive hypertension remains poorly defined, but a role for nitric oxide (NO) has been suggested. The Dahl/Rapp salt-sensitive rat possesses a defect in NO synthesis that is overcome by supplementation with L-arginine, which increases NO and cGMP production and prevents salt-sensitive hypertension. An S714P mutation of inducible NO synthase (NOS2) was subsequently identified. The...

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Source

Identifiers

PMID: 11509447
DOI: 10.1161/hh1601.094625

Genes

NOS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nitric oxide synthase (NOS2) mutation in Dahl/Rapp rats decreases enzyme stability.PMID 11509447Read ↗

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