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Article

Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation.

Biochemistry - 24 May 2011

Baskaran Padmamalini, Heckler Erin J, van den Akker Focco, Beuve Annie

Abstract excerpt

Nitric oxide (NO) is involved in the physiology and pathophysiology of the cardiovascular and neuronal systems via activation of soluble guanylyl cyclase (sGC), a heme-containing heterodimer. Recent structural studies have allowed a better understanding of the residues that dictate the affinity and binding of NO to the heme and the resulting breakage of the bond between the heme iron and histidine 105 (H105) of...

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PMID: 21491881
DOI: 10.1021/bi2004087
PMCID: PMC3313552

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Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation.PMID 21491881Read ↗

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