Article
Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.
The Journal of biological chemistry - 13 Mar 2009
Chen Ting, Li Meng, Ding Yu, Zhang Le-Shuai, Xi Ying, Pan Wei-Jun, Tao Dong-Lei, Wang Ji-Yong, Li Lin
Abstract excerpt
Axin, a key modulator of the Wnt/beta-catenin pathway, acts as a scaffold protein in phosphorylating and degrading cytoplasmic beta-catenin. Canonical Wnt proteins appear to stabilize beta-catenin by inducing the interaction of LRP5/6 with Axin. This interaction requires the phosphorylation of the Ser or Thr residues in the PPPP(S/T)PX(T/S) motifs at the intracellular domain of LRP5/6. In this work, we identified...
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