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Article

TBX3 acts as tissue-specific component of the Wnt/β-catenin enhanceosome

2020-04-22

Abstract excerpt

BCL9 and PYGO are β-catenin cofactors that enhance the transcription of Wnt target genes. They have been proposed as therapeutic targets to diminish Wnt signalling output in intestinal malignancies. Here we find that, in colorectal cancer cells and in developing mouse forelimbs, BCL9 proteins sustain the action of β-catenin in a largely PYGO-independent manner. Our genetic analyses implied that BCL9 necessitates o...

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Identifiers and source

Literature Corpus work
a54593dc-b4e4-5732-9f62-0294867e2c0f
DOI
10.1101/2020.04.22.053561
Open publication

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TBX3 acts as tissue-specific component of the Wnt/β-catenin enhanceosomeDOI 10.1101/2020.04.22.053561
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