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RNF43 and ZNRF3 in Wnt Signaling - A Master Regulator at the Membrane

20 Jul 2023

Abstract excerpt

-catenin signaling pathway is a highly conserved mechanism that plays a critical role from embryonic development and adult stem cell homeostasis. However, dysregulation of the Wnt pathway has been implicated in various diseases, including cancer. Therefore, multiple layers of regulatory mechanisms tightly control the activation and suppression of the Wnt signal. The E3 ubiquitin ligases RNF43 and ZNRF3, which are...

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PMID: 37643759
DOI: 10.15283/ijsc23070

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