Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biochemical characterization of the Drosophila axin protein.

FEBS letters - 2 Jun 2000

Yanagawa S, Lee J S, Matsuda Y, Ishimoto A

Abstract excerpt

In the Wnt/Wingless pathway, accumulation of beta-catenin/Armadillo protein is a key regulatory step. Vertebrate Axin is a negative regulator of Wnt signaling, promoting glycogen synthase kinase-3beta-mediated phosphorylation of beta-catenin and thereby destabilizing beta-catenin. Using Drosophil...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Armadillo Domain Proteins
Share to Axin Protein
Share to Dishevelled Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3

Share to High Mobility Group Proteins

Share to Phosphoprotein Phosphatases

Share to Protein Phosphatase 2

Share to Wnt1 Protein

Source

Identifiers

PMID: 10838083
DOI: 10.1016/s0014-5793(00)01601-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10838083-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biochemical characterization of the Drosophila axin protein.PMID 10838083Read ↗

Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.Semantic proximity Read ↗

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo.Semantic proximity Read ↗

The links between axin and carcinogenesisSemantic proximity Read ↗

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.Semantic proximity Read ↗

Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling.Semantic proximity Read ↗

The structural and functional determinants of the Axin and Dishevelled DIX domains.Semantic proximity Read ↗

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3βSemantic proximity Read ↗

Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.Semantic proximity Read ↗

Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.Semantic proximity Read ↗

Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo.Semantic proximity Read ↗

The effect of Wnt signaling on the localization, molecular size and activity of the beta-catenin destruction complex in vivoSemantic proximity Read ↗

E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.