Article
Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining.
Molecular and cellular biology - 1 Jul 2015
Jessulat Matthew, Malty Ramy H, Nguyen-Tran Diem-Hang, Deineko Viktor, Aoki Hiroyuki, Vlasblom James, Omidi Katayoun, Jin Ke, Minic Zoran, Hooshyar Mohsen, Burnside Daniel, Samanfar Bahram, Phanse Sadhna, Freywald Tanya, Prasad Bhanu, Zhang Zhaolei, Vizeacoumar Franco, Krogan Nevan J, Freywald Andrew, Golshani Ashkan, Babu Mohan
Abstract excerpt
The nonhomologous end-joining (NHEJ) pathway is essential for the preservation of genome integrity, as it efficiently repairs DNA double-strand breaks (DSBs). Previous biochemical and genetic investigations have indicated that, despite the importance of this pathway, the entire complement of genes regulating NHEJ remains unknown. To address this, we employed a plasmid-based NHEJ DNA repair screen in budding yeast...
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