Article
The TRIB3 R84 variant is associated with increased left ventricular mass in a sample of 2426 White individuals.
Cardiovascular diabetology - 29 May 2021
Mannino Gaia Chiara, Averta Carolina, Fiorentino Teresa Vanessa, Succurro Elena, Spiga Rosangela, Mancuso Elettra, Miceli Sofia, Perticone Maria, Sciacqua Angela, Andreozzi Francesco, Sesti Giorgio
Abstract excerpt
BACKGROUND: Prior studies in animal models showed that increased cardiac expression of TRIB3 has a pathogenic role in inducing left ventricular mass (LVM). Whether alterations in TRIB3 expression or function have a pathogenic role in inducing LVM increase also in humans is still unsettled. In order to address this issue, we took advantage of a nonsynonymous TRIB3 Q84R polymorphism (rs2295490), a gain-of-function...
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