Article
Integrative in silico analysis identifies functionally and regulatively relevant nsSNPs in the TRIB3 gene.
Computational biology and chemistry - 1 Oct 2026
Almramhi Mona M, Alsubhi Sereen Y, Alzahrani Bdoor M, Eissa Fai A, AlDossari Manar I, Tounsi Wajnat A, Almars Amany I
Abstract excerpt
BACKGROUND: To date, a single missense variant (Q84R) in TRIB3 (Tribbles pseudokinase 3) has been experimentally characterised. Hence, the functional relevance of the vast majority of reported TRIB3 nonsynonymous single-nucleotide polymorphisms (nsSNPs) remains largely unexplored. METHOD: We conducted a multi-layered in silico analysis to prioritise TRIB3 nsSNPs with the highest likelihood of disrupting protein...
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