Article
The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells.
Cardiovascular research - 1 Jan 2011
Formoso Gloria, Di Tomo Pamela, Andreozzi Francesco, Succurro Elena, Di Silvestre Sara, Prudente Sabrina, Perticone Francesco, Trischitta Vincenzo, Sesti Giorgio, Pandolfi Assunta, Consoli Agostino
Abstract excerpt
AIMS: TRIB3, a mammalian tribbles homologue, affects insulin signalling and action by inhibiting Akt phosphorylation. A TRIB3 Q84R gain-of-function polymorphism has been associated with insulin resistance both in vitro and in vivo and with several atherosclerotic phenotypes, including increased carotid intima-media thickness (IMT). We wanted to replicate this latter association and, if so, to get deeper insights...
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