Article
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice.
The Journal of cell biology - 12 Jan 2009
Wang Xin, Rao Raghavendra Pralhada, Kosakowska-Cholody Teresa, Masood M Athar, Southon Eileen, Zhang Helin, Berthet Cyril, Nagashim Kunio, Veenstra Timothy K, Tessarollo Lino, Acharya Usha, Acharya Jairaj K
Abstract excerpt
Ceramide transfer protein (CERT) functions in the transfer of ceramide from the endoplasmic reticulum (ER) to the Golgi. In this study, we show that CERT is an essential gene for mouse development and embryonic survival and, quite strikingly, is critical for mitochondrial integrity. CERT mutant embryos accumulate ceramide in the ER but also mislocalize ceramide to the mitochondria, compromising their function....
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