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Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation.

Stem cells (Dayton, Ohio) - 14 Dec 2023

Pu Jing, Kofuji Satoshi, Okamoto-Uchida Yoshimi, Danzaki Keiko, Yu Ruoxing, Suzuki Akira, Kitajima Satoshi, Nishina Hiroshi

Abstract excerpt

In early embryogenesis, the primitive streak (PrS) generates the mesendoderm and is essential for organogenesis. However, because the PrS is a minute and transient tissue, elucidating the mechanism of its formation has been challenging. We performed comprehensive screening of 2 knockout mouse databases based on the fact that failure of PrS formation is lethal. We identified 812 genes involved in various cellular...

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PMID: 37819786
DOI: 10.1093/stmcls/sxad071
PMCID: PMC10722545

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