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Article

Molecular machinery for non-vesicular trafficking of ceramide.

Nature - 18 Dec 2003

Hanada Kentaro, Kumagai Keigo, Yasuda Satoshi, Miura Yukiko, Kawano Miyuki, Fukasawa Masayoshi, Nishijima Masahiro

Abstract excerpt

Synthesis and sorting of lipids are essential for membrane biogenesis; however, the mechanisms underlying the transport of membrane lipids remain little understood. Ceramide is synthesized at the endoplasmic reticulum and translocated to the Golgi compartment for conversion to sphingomyelin. The main pathway of ceramide transport to the Golgi is genetically impaired in a mammalian mutant cell line, LY-A. Here we...

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PMID: 14685229
DOI: 10.1038/nature02188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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