Article
Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.
Cell metabolism - 8 Jun 2011
Zhang Ji, Guan Ziqiang, Murphy Anne N, Wiley Sandra E, Perkins Guy A, Worby Carolyn A, Engel James L, Heacock Philip, Nguyen Oanh Kim, Wang Jonathan H, Raetz Christian R H, Dowhan William, Dixon Jack E
Abstract excerpt
PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown. Herein, we demonstrate that whole body deletion of Ptpmt1 in mice leads to embryonic lethality, suggesting an indispensable role for PTPMT1 during development. Ptpmt1 deficiency in mouse embryonic fibroblasts compromises mitochondrial respiration and results in abnormal mitochondrial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.