Acute leukemia in children with Down syndrome

Abstract excerpt

Down syndrome or constitutional trisomy 21(OMIN#190685) was linked to leukemia for the firsttime in a case report published in 1930.1 Since then, Down syndrome has been recognized as one of the most important leukemia-predisposing syndromes and patients with Down syndrome and leukemia have unique clinical fea-tures and significant differences in treatment response and toxicity profiles compared to patients...