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Article

Loss of heterozygosity analysis using whole genome amplification, cell sorting, and fluorescence-based PCR.

Genome research - 1 May 1999

Paulson T G, Galipeau P C, Reid B J

Abstract excerpt

Loss of heterozygosity (LOH) is a common genetic lesion found in many human neoplasms. Extending investigation of LOH to large-scale clinical and public health science studies has proven difficult because of the small size and cellular and genetic heterogeneity of human neoplasms, in addition to the challenges associated with increasing throughput. Our approach to LOH analysis was developed using clinical biopsy...

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Identifiers

PMID: 10330128
PMCID: PMC310769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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