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Article

A novel functional haplotype in the human GNAS gene alters Galphas expression, responsiveness to beta-adrenoceptor stimulation, and peri-operative cardiac performance.

European heart journal - 1 Jun 2009

Frey Ulrich H, Adamzik Michael, Kottenberg-Assenmacher Eva, Jakob Heinz, Manthey Iris, Broecker-Preuss Martina, Bergmann Lars, Heusch Gerd, Siffert Winfried, Peters Jürgen, Leineweber Kirsten

Abstract excerpt

AIMS: Cardiac overexpression of the beta-adrenoceptor-coupled G-protein subunit Galphas in mice enhances inotropic responses to sympathetic stimulation, but evokes cardiomyopathy with increasing age. We tested whether functional single nucleotide polymorphisms (SNPs) in the human Galphas (GNAS) gene modulate Galphas expression and assessed functional consequences. METHODS AND RESULTS: Sequencing the promoter and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, Gs

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Source

Identifiers

PMID: 19136681
DOI: 10.1093/eurheartj/ehn572

Genes

GNAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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