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Article

Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives.

Hypertension (Dallas, Tex. : 1979) - 1 Mar 2006

Riddle Evan L, Rana Brinda K, Murthy Kenton K, Rao Fangwen, Eskin Eleazar, O'Connor Daniel T, Insel Paul A

Abstract excerpt

Regulator of G protein signaling (RGS) proteins stimulate the GTPase activity of Galpha subunits of heterotrimeric G proteins, thereby negatively regulating G protein-coupled receptor signaling. RGS2, which preferentially alters Galphaq-mediated signaling, may be important for cardiovascular health, because knockout of RGS2 in mice is associated with altered smooth muscle relaxation and hypertension. In this...

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Identifiers

PMID: 16432041
DOI: 10.1161/01.HYP.0000200714.81990.61

Genes

RGS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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