Article
RGS4 reduces contractile dysfunction and hypertrophic gene induction in Galpha q overexpressing mice.
Journal of molecular and cellular cardiology - 1 Feb 2001
Rogers J H, Tsirka A, Kovacs A, Blumer K J, Dorn G W, Muslin A J
Abstract excerpt
The intrinsic GTPase activity of Galpha q is low, and RGS proteins which activate GTPase are expressed in the heart; however, their functional relevance in vivo is unknown. Transgenic mice with cardiac-specific overexpression of Galpha q in myocardium exhibit cardiac hypertrophy, enhanced PKC xi membrane translocation, embryonic gene expression, and depressed cardiac contractility. We recently reported that...
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