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Article

GNAS gene variants affect β-blocker-related survival after coronary artery bypass grafting.

Anesthesiology - 1 May 2014

Frey Ulrich H, Muehlschlegel Jochen D, Ochterbeck Christoph, Fox Amanda A, Shernan Stanton K, Collard Charles D, Lichtner Peter, Peters Jürgen, Body Simon

Abstract excerpt

BACKGROUND: Cardiac overexpression of the β-adrenoreceptor (βAR)-coupled stimulatory G-protein subunit Gαs enhances inotropic responses to adrenergic stimulation and improves survival in mice under βAR blockade. The authors recently identified three common haplotypes in the GNAS gene encoding Gαs, with the greatest Gαs protein expression and signal transduction in haplotype *3 carriers and less in haplotype *2...

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Share to Adrenergic beta-Antagonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24755784
DOI: 10.1097/ALN.0000000000000189
PMCID: PMC4070180

Genes

GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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