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Article

A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.

Nature medicine - 1 May 2008

Liggett Stephen B, Cresci Sharon, Kelly Reagan J, Syed Faisal M, Matkovich Scot J, Hahn Harvey S, Diwan Abhinav, Martini Jeffrey S, Sparks Li, Parekh Rohan R, Spertus John A, Koch Walter J, Kardia Sharon L R, Dorn Gerald W

Abstract excerpt

Beta-adrenergic receptor (betaAR) blockade is a standard therapy for cardiac failure and ischemia. G protein-coupled receptor kinases (GRKs) desensitize betaARs, suggesting that genetic GRK variants might modify outcomes in these syndromes. Re-sequencing of GRK2 and GRK5 revealed a nonsynonymous polymorphism of GRK5, common in African Americans, in which leucine is substituted for glutamine at position 41....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18425130
DOI: 10.1038/nm1750
PMCID: PMC2596476

Genes

GRK5
GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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