Article
Discordant genotypic interpretation and phenotypic role of protease mutations in HIV-1 subtypes B and G.
The Journal of antimicrobial chemotherapy - 1 Mar 2009
Santos André F, Abecasis Ana B, Vandamme Anne-Mieke, Camacho Ricardo J, Soares Marcelo A
Abstract excerpt
OBJECTIVES: HIV-1 group M is classified into nine different subtypes. Most antiretroviral (ARV) drugs have been developed for subtype B, and the response of non-B subtypes in terms of susceptibility and the acquisition of drug resistance when facing those drugs is largely unknown. In this study, we aimed to address differences in the impact of protease inhibitor (PI)-selected mutations on subtypes B and G....
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