Article
Genotypic and phenotypic evidence of different drug-resistance mutation patterns between B and non-B subtype isolates of human immunodeficiency virus type 1 found in Brazilian patients failing HAART.
Virus genes - 1 Jan 2001
Caride E, Hertogs K, Larder B, Dehertogh P, Brindeiro R, Machado E, de Sá C A, Eyer-Silva W A, Sion F S, Passioni L F, Menezes J A, Calazans A R, Tanuri A
Abstract excerpt
We have investigated the phenotypic and genotypic susceptibility of 14 HIV-1 strains isolated from individuals failing HAART therapy to protease inhibitors (PI). Proviral and plasma viral pol gene fragment were amplified, sequenced and subtyped. Nine samples clustered with protease subtype B reference strains and the remaining samples were classified as non-B subtype corresponding to subtype F (n = 4) and subtype...
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