Article
Discordances between interpretation algorithms for genotypic resistance to protease and reverse transcriptase inhibitors of human immunodeficiency virus are subtype dependent.
Antimicrobial agents and chemotherapy - 1 Feb 2006
Snoeck Joke, Kantor Rami, Shafer Robert W, Van Laethem Kristel, Deforche Koen, Carvalho Ana Patricia, Wynhoven Brian, Soares Marcelo A, Cane Patricia, Clarke John, Pillay Candice, Sirivichayakul Sunee, Ariyoshi Koya, Holguin Africa, Rudich Hagit, Rodrigues Rosangela, Bouzas Maria Belen, Brun-Vézinet Françoise, Reid Caroline, Cahn Pedro, Brigido Luis Fernando, Grossman Zehava, Soriano Vincent, Sugiura Wataru, Phanuphak Praphan, Morris Lynn, Weber Jonathan, Pillay Deenan, Tanuri Amilcar, Harrigan Richard P, Camacho Ricardo, Schapiro Jonathan M, Katzenstein David, Vandamme Anne-Mieke
Abstract excerpt
The major limitation of drug resistance genotyping for human immunodeficiency virus remains the interpretation of the results. We evaluated the concordance in predicting therapy response between four different interpretation algorithms (Rega 6.3, HIVDB-08/04, ANRS [07/04], and VGI 8.0). Sequences were gathered through a worldwide effort to establish a database of non-B subtype sequences, and demographic and...
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