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Article

Impact of frequent natural polymorphisms at the protease gene on the in vitro susceptibility to protease inhibitors in HIV-1 non-B subtypes.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Nov 2004

Holguín Africa, Paxinos Ellen, Hertogs Kurt, Womac Chad, Soriano Vincent

Abstract excerpt

BACKGROUND: Naturally-occurring polymorphisms at the human immunodeficiency virus type 1 (HIV-1) protease which have been associated to resistance to protease inhibitors (PIs) in clade B viruses are frequently found in non-B subtypes, with unknown clinical significance. OBJECTIVE: To assess the susceptibility of non-B viruses to different PIs. STUDY DESIGN: Plasma samples from 58 drug-naive individuals infected...

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Identifiers

PMID: 15465415
DOI: 10.1016/j.jcv.2004.03.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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