Article
Description of the L76V resistance protease mutation in HIV-1 B and "non-B" subtypes.
PloS one - 1 Jan 2013
Charpentier Charlotte, Lambert-Niclot Sidonie, Alteri Claudia, Storto Alexandre, Flandre Philippe, Svicher Valentina, Perno Carlo-Federico, Brun-Vézinet Françoise, Calvez Vincent, Marcelin Anne-Geneviève, Ceccherini-Silberstein Francesca, Descamps Diane
Abstract excerpt
OBJECTIVE: To describe the prevalence of the L76V protease inhibitors resistance-associated mutation (PI-RAM) in relation with patients' characteristics and protease genotypic background in HIV-1 B- and "non-B"-infected patients. METHODS: Frequency of the L76V mutation between 1998 and 2010 was surveyed in the laboratory database of 3 clinical centers. Major PI-RAMs were identified according to the IAS-USA list....
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