Article
Effect of human immunodeficiency virus type 1 protease inhibitor therapy and subtype on development of resistance in subtypes B and G.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2010
Palma Ana Carolina, Abecasis Ana Barroso, Vercauteren Jurgen, Carvalho Ana Patricia, Cabanas Joaquim, Vandamme Anne-Mieke, Camacho Ricardo Jorge
Abstract excerpt
Europe is currently observing a significant rise in non-B subtypes. Consequently, the effect of genetic variability on therapy response or genotypic resistance interpretation algorithms is an emerging concern. The purpose of this study is to investigate the amino acid substitutions selected under drug pressure in the protease of human immunodeficiency virus type 1 (HIV-1) subtypes B and G, and determine if there...
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