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Article

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.

Genes & development - 1 Jan 2009

Prakash Rohit, Satory Dominik, Dray Eloïse, Papusha Almas, Scheller Jürgen, Kramer Wilfried, Krejci Lumir, Klein Hannah, Haber James E, Sung Patrick, Ira Grzegorz

Abstract excerpt

Eukaryotes possess mechanisms to limit crossing over during homologous recombination, thus avoiding possible chromosomal rearrangements. We show here that budding yeast Mph1, an ortholog of human FancM helicase, utilizes its helicase activity to suppress spontaneous unequal sister chromatid exchanges and DNA double-strand break-induced chromosome crossovers. Since the efficiency and kinetics of break repair are...

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Share to Crossing Over, Genetic
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to DNA, Fungal

Share to Mitosis

Share to Nucleic Acid Conformation

Share to Rad51 Recombinase

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Source

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Identifiers

PMID: 19136626
DOI: 10.1101/gad.1737809
PMCID: PMC2632165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.PMID 19136626Read ↗

BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism.Semantic proximity Read ↗

Mph1 requires mismatch repair-independent and -dependent functions of MutSalpha to regulate crossover formation during homologous recombination repair.Semantic proximity Read ↗

Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.Semantic proximity Read ↗

Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination.Semantic proximity Read ↗

Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1.Semantic proximity Read ↗

BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint molecules.Semantic proximity Read ↗

Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediates.Semantic proximity Read ↗

Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase.Semantic proximity Read ↗

RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.Semantic proximity Read ↗

Budding yeast Mph1 promotes sister chromatid interactions by a mechanism involving strand invasion.Semantic proximity Read ↗

Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.Semantic proximity Read ↗

Genetic evidence for a role of Saccharomyces cerevisiae Mph1 in recombinational DNA repair under replicative stress.Semantic proximity Read ↗

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