Article
BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism.
Molecular cell - 13 Apr 2012
De Muyt Arnaud, Jessop Lea, Kolar Elizabeth, Sourirajan Anuradha, Chen Jianhong, Dayani Yaron, Lichten Michael
Abstract excerpt
The BLM helicase has been shown to maintain genome stability by preventing accumulation of aberrant recombination intermediates. We show here that the Saccharomyces cerevisiae BLM ortholog, Sgs1, plays an integral role in normal meiotic recombination, beyond its documented activity limiting aberrant recombination intermediates. In wild-type meiosis, temporally and mechanistically distinct pathways produce...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.