BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint molecules.

doi:10.1016/j.cell.2007.05.035

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Article

BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint molecules.

Cell - 27 Jul 2007

Oh Steve D, Lao Jessica P, Hwang Patty Yi-Hwa, Taylor Andrew F, Smith Gerald R, Hunter Neil

Abstract excerpt

Bloom's helicase (BLM) is thought to prevent crossing-over during DNA double-strand-break repair (DSBR) by disassembling double-Holliday junctions (dHJs) or by preventing their formation. We show that the Saccharomyces cerevisiae BLM ortholog, Sgs1, prevents aberrant crossing-over during meiosis by suppressing formation of joint molecules (JMs) comprising three and four interconnected duplexes. Sgs1 and...

Topics

Adenosine Triphosphatases
Chromatids
Crossing Over, Genetic
DNA Breaks, Double-Stranded
DNA Helicases
DNA, Cruciform
DNA-Binding Proteins
Meiosis
Models, Genetic
Molecular Weight
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RecQ Helicases

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Homology, Amino Acid

Sister Chromatid Exchange

Transcription Factors

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Identifiers

PMID: 17662941
DOI: 10.1016/j.cell.2007.05.035
PMCID: PMC2034285

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BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint molecules.PMID 17662941Read ↗

BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism.Semantic proximity Read ↗

Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase.Semantic proximity Read ↗

RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.Semantic proximity Read ↗

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.Semantic proximity Read ↗

Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.Semantic proximity Read ↗

Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.Semantic proximity Read ↗

mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.Semantic proximity Read ↗

DNA helicases Sgs1 and BLM promote DNA double-strand break resection.Semantic proximity Read ↗

Regulation of the MLH1-MLH3 endonuclease in meiosisSemantic proximity Read ↗

The fission yeast BLM homolog Rqh1 promotes meiotic recombination.Semantic proximity Read ↗

Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis.Semantic proximity Read ↗

An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.Semantic proximity Read ↗

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