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RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.

Molecular cell - 8 Aug 2008

Oh Steve D, Lao Jessica P, Taylor Andrew F, Smith Gerald R, Hunter Neil

Abstract excerpt

Saccharomyces cerevisiae RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, are implicated in processing joint molecule (JM) recombination intermediates. We show that cells lacking either enzyme frequently experience chromosome segregation problems during meiosis and that when both enzymes are absent attempted segregation fails catastrophically. In all cases, segregation appears to be impeded by...

Topics

Chromosome Segregation
Crossing Over, Genetic
Cyclin B
DNA Breaks, Double-Stranded
DNA, Cruciform
DNA-Binding Proteins
Endonucleases
Flap Endonucleases
Meiosis
Mutation
RecQ Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Time Factors

Trans-Activators

Source

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Identifiers

PMID: 18691965
DOI: 10.1016/j.molcel.2008.07.006
PMCID: PMC2587322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.PMID 18691965Read ↗

Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.Semantic proximity Read ↗

Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase.Semantic proximity Read ↗

BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism.Semantic proximity Read ↗

BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint molecules.Semantic proximity Read ↗

Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediates.Semantic proximity Read ↗

Meiotic recombination intermediates are resolved with minimal crossover formation during return-to-growth, an analogue of the mitotic cell cycle.Semantic proximity Read ↗

Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions.Semantic proximity Read ↗

Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease.Semantic proximity Read ↗

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.Semantic proximity Read ↗

Single Holliday junctions are intermediates of meiotic recombination.Semantic proximity Read ↗

Controlling meiotic recombinational repair - specifying the roles of ZMMs, Sgs1 and Mus81/Mms4 in crossover formation.Semantic proximity Read ↗

Processing of homologous recombination repair intermediates by the Sgs1-Top3-Rmi1 and Mus81-Mms4 complexesSemantic proximity Read ↗

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