Article
Fibrinogen genes modify the fibrinogen response to ambient particulate matter.
American journal of respiratory and critical care medicine - 15 Mar 2009
Peters Annette, Greven Sonja, Heid Iris M, Baldari Fiammetta, Breitner Susanne, Bellander Tom, Chrysohoou Christina, Illig Thomas, Jacquemin Bénédicte, Koenig Wolfgang, Lanki Timo, Nyberg Fredrik, Pekkanen Juha, Pistelli Riccardo, Rückerl Regina, Stefanadis Christodoulos, Schneider Alexandra, Sunyer Jordi, Wichmann H Erich
Abstract excerpt
RATIONALE: Ambient particulate matter has been associated with systemic inflammation indicated by blood markers such as fibrinogen, implicated in promoting atherothrombosis. OBJECTIVES: This study evaluated whether single-nucleotide polymorphisms (SNPs) within the fibrinogen genes modified the relationship between ambient particles and plasma fibrinogen. METHODS: In 854 myocardial infarction survivors from five...
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