Article
Genotype-by-diet effects on co-variation in Lp-PLA2 activity and LDL-cholesterol concentration in baboons fed an atherogenic diet.
Journal of lipid research - 1 Jun 2008
Vinson Amanda, Mahaney Michael C, Diego Vince P, Cox Laura A, Rogers Jeffrey, VandeBerg John L, Rainwater David L
Abstract excerpt
Both lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity, a biomarker of inflammation, and concentration of its primary associated lipoprotein, LDL, are correlated with adverse coronary outcomes. We previously reported a quantitative trait locus (QTL) corresponding to HSA2p24.3-p23.2 with pleiotropic effects on Lp-PLA(2) activity and LDL-cholesterol (LDL-C) concentration in baboons fed a basal diet....
Topics
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
- Animals
- Cholesterol, LDL
- Dietary Fats
- Female
- Genetic Predisposition to Disease
- Genotype
- Male
- Papio
- Quantitative Trait Loci
- Risk Factors