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Article

Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia.

Archives of general psychiatry - 1 Jan 2009

Small Gary W, Siddarth Prabha, Burggren Alison C, Kepe Vladimir, Ercoli Linda M, Miller Karen J, Lavretsky Helen, Thompson Paul M, Cole Greg M, Huang S C, Phelps Michael E, Bookheimer Susan Y, Barrio Jorge R

Abstract excerpt

CONTEXT: Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of Alzheimer disease that accumulate in the brains of people without dementia years before they develop dementia. Positron emission tomography (PET) scans after intravenous injections of 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP), which binds to plaques and tangles in...

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Identifiers

PMID: 19124691
DOI: 10.1001/archgenpsychiatry.2008.516
PMCID: PMC2693405

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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