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Article

Brain Amyloid Deposition and Longitudinal Cognitive Decline in Nondemented Older Subjects: Results from a Multi-Ethnic Population.

PloS one - 1 Jan 2015

Gu Yian, Razlighi Qolamreza R, Zahodne Laura B, Janicki Sarah C, Ichise Masanori, Manly Jennifer J, Devanand D P, Brickman Adam M, Schupf Nicole, Mayeux Richard, Stern Yaakov

Abstract excerpt

OBJECTIVE: We aimed to whether the abnormally high amyloid-β (Aβ) level in the brain among apparently healthy elders is related with subtle cognitive deficits and/or accelerated cognitive decline. METHODS: A total of 116 dementia-free participants (mean age 84.5 years) of the Washington Heights Inwood Columbia Aging Project completed 18F-Florbetaben PET imaging. Positive or negative cerebral Aβ deposition was...

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Identifiers

PMID: 26221954
DOI: 10.1371/journal.pone.0123743
PMCID: PMC4519341

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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