Article
Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET.
Neurology - 2 Feb 2021
La Joie Renaud, Visani Adrienne V, Lesman-Segev Orit H, Baker Suzanne L, Edwards Lauren, Iaccarino Leonardo, Soleimani-Meigooni David N, Mellinger Taylor, Janabi Mustafa, Miller Zachary A, Perry David C, Pham Julie, Strom Amelia, Gorno-Tempini Maria Luisa, Rosen Howard J, Miller Bruce L, Jagust William J, Rabinovici Gil D
Abstract excerpt
OBJECTIVE: To assess whether Alzheimer disease (AD) clinical presentation and APOE4 relate to the burden and topography of β-amyloid (Aβ) and tau pathologies using in vivo PET imaging. METHODS: We studied 119 Aβ-positive symptomatic patients aged 48-95 years, including 29 patients with logopenic variant primary progressive aphasia (lvPPA) and 21 with posterior cortical atrophy (PCA). Pittsburgh compound B...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.